Sunday, April 5, 2009

How does this small product pack such a punch??

How can a small strip pack so much punch? The Enlyten product line and delivery system is going to take the market by storm.

Enlyten delivery system technology:

http://www.enlyten.com/Technology.aspx?ID=mgrass


R.A.S.E.R. Technology: Was developed to take advantage of the benefits that buccal mucosa delivery may provide. Rapid-Acting, Side-Effect-Reducing.

Bi-Layer Strip Matrix: Our patent pending, exclusive, dual layer strips provide greater capacity to maximize the quantity of active ingredients and flavors.

Fast & Efficient: Recent studies indicate that delivery through the buccal mucosa region may deliver double the bio-availability of active ingredients at more than two to three times the rate of absorption, compared with products that rely exclusively on digestion through the GI tract.

http://www.pharmainfo.net/reviews/current-status-buccal-drug-delivery-system

Advantages Of Drug Delivery Via The Buccal Lining : 2, 5

  1. Bypass of the gastrointestinal tract and hepatic portal system, increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism . In addition the drug is protected from degradation due to pH and digestive enzymes of the middle gastrointestinal tract
  2. Improved patient compliance due to the elimination of associated pain with injections; administration of drugs in unconscious or incapacitated patients; convenience of administration as compared to injections or oral medications.
  3. Sustained drug delivery.
  4. A relatively rapid onset of action can be achieved relative to the oral route, and the formulation can be removed if therapy is required to be discontinued.
  5. Increased ease of drug administration
  6. Though less permeable than the sublingual area, the buccal mucosa is well vascularized , and drugs can be rapidly absorbed into the venous system underneath the oral mucosa.
  7. In comparison to TDDS, mucosal surfaces do not have a stratum corneum. Thus, the major barrier layer to transdermal drug delivery is not a factor in transmucosal routes of administration. Hence transmucosal systems exhibit a faster initiation and decline of delivery than do transdermal patches.
  8. Transmucosal delivery occurs is less variable between patients, resulting in lower intersubject variability as compaired to transdermal patches.
  9. The large contact surface of the oral cavity contributes to rapid and extensive drug absorption

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