Enlyten delivery system technology:
http://www.enlyten.com/Technology.aspx?ID=mgrass
R.A.S.E.R. Technology: Was developed to take advantage of the benefits that buccal mucosa delivery may provide. Rapid-Acting, Side-Effect-Reducing.
Bi-Layer Strip Matrix: Our patent pending, exclusive, dual layer strips provide greater capacity to maximize the quantity of active ingredients and flavors.
Fast & Efficient: Recent studies indicate that delivery through the buccal mucosa region may deliver double the bio-availability of active ingredients at more than two to three times the rate of absorption, compared with products that rely exclusively on digestion through the GI tract.
http://www.pharmainfo.net/reviews/current-status-buccal-drug-delivery-system
Advantages Of Drug Delivery Via The Buccal Lining : 2, 5
- Bypass of the gastrointestinal tract and hepatic portal system, increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism . In addition the drug is protected from degradation due to pH and digestive enzymes of the middle gastrointestinal tract
- Improved patient compliance due to the elimination of associated pain with injections; administration of drugs in unconscious or incapacitated patients; convenience of administration as compared to injections or oral medications.
- Sustained drug delivery.
- A relatively rapid onset of action can be achieved relative to the oral route, and the formulation can be removed if therapy is required to be discontinued.
- Increased ease of drug administration
- Though less permeable than the sublingual area, the buccal mucosa is well vascularized , and drugs can be rapidly absorbed into the venous system underneath the oral mucosa.
- In comparison to TDDS, mucosal surfaces do not have a stratum corneum. Thus, the major barrier layer to transdermal drug delivery is not a factor in transmucosal routes of administration. Hence transmucosal systems exhibit a faster initiation and decline of delivery than do transdermal patches.
- Transmucosal delivery occurs is less variable between patients, resulting in lower intersubject variability as compaired to transdermal patches.
- The large contact surface of the oral cavity contributes to rapid and extensive drug absorption
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